TCA Cycle- Regarded as amphibolic

• TCA cycle provide many intermediates for the synthesis of many compounds needed by the body. It is actively involved in gluconeogenesis, transamination & deamination. 

• The most important anabolic reactions connected with TCA cycle are-
  
  1) Oxaloacetate and α-ketoglutarate, respectively serves as precursors for the synthesis of      aspartate and glutamate which are required for synthesis of other non essential amino acids,  purines and pyrimidines.
  
  2) Succinyl CoA is used for the synthesis of porphyrin and heme.
  
  3) Mitochondrial citrate is transported to cytosol where it is cleaved to produce acetyl CoA for the biosynthesis of fatty acids and sterols.
• TCA cylcle is both anabolic and catabolic in nature hence regarded as amphibolic .